【Research Highlights】
1. Synthetic Methodology
1.1. Amide activation-based C-C bond formation methods
One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents via Lactam/Amide Activation
1.2. SmI2-based chemistry
1.3. Chemoselective one-pot debenzylation-N-methylation
1.4. N-Acyliminium chemistry
1.4.1. Malimide-Based Synthetic Methodology and Applications
Accomplished Targets (Total or Formal Total Synthesis)
1.4.2. Piperinie series:Accomplished Targets(Total or Formal Total Synthesis)
1.5. Tetramic acids/ tetrmates series (carbanion chemistry)
2. Total synthesis of complex alkaloids
2.1. Alkaloids
2. 2. Pheromones
3. Coloborative Research
3.1. Chemical Biology
in coloboration with (1) Prof. X. K. Zhang and Y. Su; (2) Prof. Q. Wu; (3) Prof. Z. Zhang
1. Wei-jia Wang1,5, Yuan Wang1,5, Hang-zi Chen1,5, Yong-zhen Xing1,5, Feng-wei Li1,5, Qian Zhang1, Bo Zhou1, Hong-kui Zhang2, Jie Zhang2, Xue-li Bian1, Li Li1, Yuan Liu1, Bi-xing Zhao1, Yan Chen1, Rong Wu1, An-zhong Li1, Lu-ming Yao1, Ping Chen1, Yi Zhang1, Xu-yang Tian1, Friedrich Beermann3, Mian Wu4, Jiahuai Han1, Pei-qiang Huang2, Tianwei Lin1* & Qiao Wu1*, Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway, Nature Chem. Biol. 2014, published online: 8 December 2013 | doi: 10.1038/nchembio.1406.
2. Yan-yan Zhan1,4, Yan Chen, Qian Zhang1,4, Jia-jia Zhuang2, Min Tian1, Hang-zi Chen1, Lian-ru Zhang1, Hong-kui Zhang2, Jian-ping He1, Wei-jia Wang1, Rong Wu1, Yuan Wang1, Chunfang Shi1, Kai Yang1, An-zhong Li1, Yong-zhen Xin1, Terytty Yang Li1, James Y Yang1, Zhong-hui Zheng1, Chun-dong Yu1, Sheng-Cai Lin1, Chawnshang Chang3, Pei-qiang Huang2, Tianwei Lin1* & Qiao Wu1* The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK, Nature Chem. Biol. 2012, 8, 897–904. doi:10.1038/nchembio.1069.
3. Jing-jing Liu, Hui-ni Zeng, Lian-ru Zhang, Yan-yan Zhan, Yan Chen, Yuan Wang, Juan Wang, Shao-hua Xiang, Wen-jun Liu, Wei-jia Wang, Hang-zi Chen, Yue-mao Shen, Wen-jin Su, Pei-qiang Huang, Hong-kui Zhang, and Qiao Wu A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro Cancer Res. 2010, 70, 3628-3637.
4. Hu Zhou, Wen Liu, Ying Su, Zhen Wei, Jie Liu, Siva Kumar Kolluri, Hua Wu, Yu Cao, Jiebo Chen,Yin Wu, Tingdong Yan, Xihua Cao, Weiwei Gao, Andrei Molotkov, Fuquan Jiang, Wen-Gang Li, Bingzhen Lin, Hai-Ping Zhang, Jinghua Yu, Shi-Peng Luo, Jin-Zhang Zeng, Gregg Duester, Pei-Qiang Huang, and Xiao-Kun Zhang, NSAID Sulindac and Its Analog Bind RXRa and Inhibit RXRa-Dependent AKT Signaling, Cancer Cell 2010, 17, 560-573 (featured article).
3.2. Computational Chemistry in collaboration with Prof. X. Lü: J. Org. Chem. 2007, 72, 35.
4. Ongoing projects:
