Pei-Qiang Huang
Professor, Fellow of RSC
College of Chemistry and Chemical Engineering
Xiamen University
Xiamen, Fujian 361005
P. R. China
Phones: 011-86-592-218-2240;
Email: pqhuang@xmu.edu.cn
Education and Professional Experience
- B.S. in Chemistry Xiamen University 1978-1982
- D.E.A. on Organic Chemistry Université de Montpellier II, France 1983-1984
- Ph.D. on Organic Chemistry Université de Paris-XI, France, 1987 L’institut de Chimie des Substances Naturelles, CNRS 1984-1987
- Postdoctoral Fellow Shanghai Institute of Organic Chemistry, CAS 1988-1990
Academic Appointments
1990-1993 Associate Professor, Xiamen University
1993-present Professor, Xiamen University
Professional Activities
- Member of Organic Chemistry Division, Chinese Chemical Society (CCS, 2001-2018, 2019-).
- Member of Chiral Chemistry Division, Chinese Chemical Society (2018-)
- International Advisory Board Member of Eur. J. Org. Chem.( Impact Factor: 3.065) (2014-)
- Senior editorial member of Chinese J. Chemistry (Wiley);
Editorial board of
Science China – Chemistry (Springer);
Acta Chimica Sinica;
Chinese Chemical Letters（Elsevier）;
J. of Xiamen Univ.
Research Interests
- Organic synthesis; - Synthetic methodology, Asymmetric total synthesis of natural products and drugs (alkaloids, pheromones, etc).
- Chemical biology
Edited Textbook/ Book
1. Organic Named Reactions, Reagents and Rules (Second Edition), Huang, Pei-Qiang, Ed.; Chemical Industry Press, Beijing: 2019. ISBN: 9787122344038
2. Efficiency in Natural Product Total Synthesis, Huang, Pei-Qiang; Yao, Zhu-Jun; Hsung, P. Richard., Eds.; Forwarded by Prof. Hoboken, NJ: John Wiley & Sons, Inc., 2018. ISBN:9781118940228. DOI:10.1002/9781118940228
3. Organic Named Reactions, Reagents and Rules, Huang, Pei-Qiang, Ed.; Chemical Industry Press, Beijing: 2008.
4. Organic Synthesis, Huang, P.-Q.; Jin, L.-R.; Chen, A.-Q. High Education Press, Beijing: 2004.
Contributed Chapters
1. P.-Q. Huang, “Asymmetric Synthesis of Five-Membered Ring Heterocycles” in “Asymmetric Synthesis of Nitrogen Heterocycles” (J. Royer Ed.; H. P. Husson (Forwarded) Weinheim, Wiley-VCH, 2009, pp.51-94.
2. Huang, Pei-Qiang, “Asymmetric Synthesis of Alkaloids and related drugs” in Chiral Synthesis and Chiral Drugs, Lin G-Q, et al edited, Chemical Industry Press, Beijing: 2008, pp 289-308.
3. P.-Q. Huang, “Recent Advances on the Asymmetric Synthesis of Bioactive 2-Pyrrolidinone-related Compounds Starting from Enantiomeric Malic Acid” in New Methods for the Asymmetric Synthesis of Nitrogen Heterocycles, J. L. Vicario; D. Badia and L. Carrillo Ed. Research Signpost: Kerala, 2005, pp. 197-222.
4. Huang, Pei-Qiang, “Recent Progress in the Synthesis of Alkaloids” in Progress in Natural Products, De-Quan Yu and Yu-Lin Wu, edited, Chemical Industry Press, Beijing: 2005, pp.599-634.
5. Huang, Pei-Qiang “Modern Organic Synthesis” in Strategies in the Development of Organic Synthesis in the 21th Century, Du, C.-P.; Liu, L.-S.; Zhang, H. edited, Chemical Industry Press, Beijing: 2002, pp.57-79.
6. Huang, Pei-Qiang “Asymmetric Cycloadditions” in Asymmetric Synthesis and Catalysis (in Chinese), Yang, D.-K.; et al edited, Foundation for Cultural and Education of Chung-Xin University, Taichung: 1998, pp.57-87.
Representative Publications
1. Amides as Surrogates of Aldehydes for C-C Bond Formation: Amide-Based Direct Knoevenagel-Type Condensation Reaction and Related Reactions Ou W.; Huang P.-Q. Sci. China-Chem. 2020, 63, 11-15.
2. Ni-Catalyzed Direct Alcoholysis of N-Acylpyrrole-Type Tertiary Amides under Mild Conditions, Hang Chen, Dong-Huang Chen and Pei-Qiang Huang, Sci. China-Chem. 2020, 63, 370-376.
3. Organocatalytic, Enantioselective Reductive Bis-Functionalization of Secondary Amides: One-pot Construction of Chiral 2,2-Disubstituted 3-Iminoindoline, Zhen Xu, Xiao-Gang Wang, Yong-Hua Wei, Kan-Lei Ji, Jian-Feng Zheng*, Jian-Liang Ye* and Pei-Qiang Huang* Org. Lett. 2019, 21, 7587-7591.
4. Chemoselective Synthesis of a-Amino-a-cyanophosphonates by Reductive Gem-Cyanation-Phosphonylation of Secondary Amides, Ting-Ting Chen, Ai-E Wang,* and Pei-Qiang Huang*, Org. Lett. 2019, 21, 3808-3812.
5. Intermolecular Dehydrative [4 + 2] Aza-Annulation of N-Arylamides with Alkenes: A Direct and Divergent Entrance to Aza-Heterocycles, Ying-Hong Huang, Shu-Ren Wang, Dong-Ping Wu, and Pei-Qiang Huang,* Org. Lett. 2019, 21, 1681-1685.
6. Biomimetic Enantioselective Total Synthesis of (–)-Robustanoids A, B and Analogs, Zhan-Jiang Liu and Pei-Qiang Huang,* J. Org. Chem. 2019, 84, 5627-5634.(The publication was selected as one of the 40 leading articles on natural products chemistry from ACS core organic journals during 2019.)
7. Enamines as Surrogates of Alkyl Carbanions for the Direct Conversion of Secondary Amides to a-Branching Ketones, Yong-Peng Liu, Shu-Ren Wang, Ting-Ting Chen, Cun-Cun Yu, Ai-E Wang* and Pei-Qiang Huang,* Adv. Synth. Catal. 2019, 361, 971-975.
8. A stepwise annulation for the transformation of cyclic ketones to fused 6 and 7-membered cyclic enimines and enones, Dong-Ping Wu, Qian He, Dong-Huang Chen, Jian-Liang Ye, and Pei-Qiang Huang,* Chin. J. Chem. 2019, 37, 315-322.
The publication won the NHU-CJC Innovation Award (2019)! Our method was used by other research groups for the total synthesis of Daphniphyllum alkaloids with complex structures.
9. Direct Transformation of Amides: Reductive Cycloaddition of Secondary Amides with Danishefsky Diene, Jian-Feng Zheng,* Zhi-Qiang Xie, Xin-Jian Chen, and Pei-Qiang Huang* Acta Chim. Sinica 2015, 73, 705-715. The publication won the Most Influential-Paper Award of Acta Chimica Sinica（2017）
10. A Concise Formal Stereoselective Total Synthesis of (-)-Swainsonine, X.-G. Wang, A. E Wang, and P.-Q. Huang,* Chinese Chem. Lett. 2014, 23, 193-196. The publication won the High-impact-Paper Award of Chinese Chemical Letters (2015, 2016)!
11. Iridium-Catalyzed Reductive Alkylations of Secondary Amides, Wei Ou, Feng Han, Xiu-Ning Hu, Hang Chen, and Pei-Qiang Huang, Angew. Chem. Int. Ed. 2018, 57, 11354 –11358.
12. A Versatile One-Pot Synthesis of Polysubstituted Cyclopent-2-enimines from α,β-Unsaturated Amides via Imino-Nazarov Reaction, Ting Fan, Ao Wang, Jia-Qi Li, Jian-Liang Ye, Xiao Zheng, and Pei-Qiang Huang, Angew. Chem. Int. Ed. 2018, 57, 10352 –10356.
13. Dual Catalysis for Enantioselective Convergent Synthesis of Enantiopure Vicinal Amino Alcohols,Chen-Xi Ye, Yared Yohannes Melcamu, Heng-Hui Li, Jiang-Tao Cheng, Tian-Tian Zhang, Yuan-Ping Ruan, Xiao Zheng, Xin Lu, and Pei-Qiang Huang, Nature Commun. 2018, 9:410. (highlighted by Synform, Sci. China: Chem, Chinese Science Bulletin)
14. Organocatalytic, Asymmetric Total Synthesis of (-)-Haliclonin A. Lian-Dong Guo, Xiong-Zhi Huang, Shi-Peng Luo, Wen-Sen Cao, Yuan-Ping Ruan, Jian-Liang Ye, Pei-Qiang Huang, Angew. Chem., Int. Ed. 2016, 55, 4064-4068.
15. Titanocene(III)-Catalyzed Three-Component Reaction of Secondary Amides, Aldehydes, and Electrophilic Alkenes. Xiao Zheng, Jiang He, Heng-Hui Li, Ao Wang, Xi-Jie Dai, Ai-E Wang, Pei-Qiang Huang, Angew. Chem., Int. Ed. 2015, 54, 13739-13742.
16. Umpolung of Hemiaminals: Titanocene-Catalyzed Dehydroxylative Radical Coupling Reactions with Activated Alkenes. Xiao Zheng, Xi-Jie Dai, Hong-Qiu Yuan, Chen-Xi Ye, Jie Ma, Pei-Qiang Huang, Angew. Chem., Int. Ed. 2013, 52, 3494-3498.
17. Direct Transformation of Secondary Amides into Secondary Amines: Triflic Anhydride Activated Reductive Alkylation. Kai-Jiong Xiao, Ai-E Wang, Pei-Qiang Huang, Angew. Chem., Int. Ed. 2012, 51, 8314-8317.
18. Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation. Kai-Jiong Xiao, Jie-Min Luo, Ke-Yin Ye, Yu Wang, Pei-Qiang Huang, Angew. Chem., Int. Ed. 2010, 49, 3037-3040.
(highlighted by Nature Chem. and synthfacts)
19. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Li Li, Yuan Liu, Hang-zi Chen, Feng-wei Li, Jian-feng Wu, Hong-kui Zhang, Jian-ping He, Yong-zhen Xing, Yan Chen, Wei-jia Wang, Xu-yang Tian, An-zhong Li, Qian Zhang, Pei-qiang Huang, Jia-huai Han, Tian-wei Lin, Qiao Wu, Nat. Chem. Biol. 2015, 11, 339-346.
20. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Wei-jia Wang, Yuan Wang, Hang-zi Chen, Yong-zhen Xing, Feng-wei Li, Qian Zhang, Bo Zhou, Hong-kui Zhang, Jie Zhang, Xue-li Bian, Li Li, Yuan Liu, Bi-xing Zhao, Yan Chen, Rong Wu, An-zhong Li, Lu-ming Yao, Ping Chen, Yi Zhang, Xu-yang Tian, Friedrich Beermann, Mian Wu, Jia-huai Han, Pei-qiang Huang, Tian-wei Lin, Qiao Wu, Nat. Chem. Biol. 2014, 10, 133-140.
21. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Yan-yan Zhan, Yan Chen, Qian Zhang, Jia-jia Zhuang, Min Tian, Hang-zi Chen, Lian-ru Zhang, Hong-kui Zhang, Jian-ping He, Wei-jia Wang, Rong Wu, Yuan Wang, Chun-fang Shi, Ka i Yang, An-zhong Li, Yong-zhen Xin, Terytty Yang Li, James Y. Yang, Zhong-hui Zheng, Chun-dong Yu, Sheng-Cai Lin, Chawnshang Chang, Pei-qiang Huang, Tian-wei Lin, Qiao Wu, Nat. Chem. Biol. 2012, 8, 897-904.
22. NSAID Sulindac and Its Analog Bind RXR alpha and Inhibit RXR alpha-Dependent AKT Signaling. Hu Zhou, Wen Liu, Ying Su, Zhen Wei, Jie Liu, Siva Kumar Kolluri, Hua Wu, Yu Cao, Jie-bo Chen, Yin Wu, Ting-dong Yan, Xi-hua Cao, Wei-wei Gao, Andrei Molotkov, Fu-quan Jiang, Wen-Gang Li, Bing-zhen Lin, Hai-Ping Zhang, Jing-hua Yu, Shi-Peng Luo, Jin-Zhang Zeng, Gregg Duester, Pei-Qiang Huang, Xiao-Kun Zhang, Cancer Cell 2010, 17, 560-573.
